Identification of Metabolites of Drugs of Abuse - e.g., of the type that Olympic athletes are routinely test for and which can be used not only to introduce GC-MS and MS2 techniques, but also to teach human metabolism chemistry. Analysis of Polymer Polydispersivity, e.g., of the type that industrial research typically conduct as they attempt to prepare new materials and which can be used not only to introduce the difficulty of ionizing some of the bulk polymers used in everyday living but can be used to introduce and contrast classical methods, such as GPC, that address the same question. Download a PDF document describing thoughts, plans, and progress on this case study. Fundamental Molecular Properties; numerous cases studies can be designed to demonstrate how mass spectrometry is used to provide information about intrinsic molecular properties such as acidities, either gas-phasei or predictions for water,ii or reaction competition as in the case of SN2 versus E2 reactions.iii Determination if Mine Leachates are Polluting a Local Stream - e.g., by analyzing isotope ratios of selected metal ions, one can determine if water flows might be moving metals out of tailing piles into fresh water sources. Environmental Sample Analysis - e.g., identification of compounds and their relative concentrations, in the Chemistry building, using the SIFT and its capabilities for Real-Time Environmental Monitoring via Proton or Charge Transfer Reactions. Protein Purity - e.g., analysis of an isolated and purified protein or known enzyme from a Biochemistry Laboratory course to compare authenticity and purity as determined by MS versus the standard gel electrophoretic techniques. Unknown Compound Identification - e.g., use high resolution MS to examine drugs of abuse and designer drug versions thereof. Identification of Modified DNA - e.g., use the sequencing capability of either ESI Ion Traps or MALDI-TOF instruments to characterize an olgionucleotide and to specifically identify a unique chemical modification therein.